Effects of Donor Age and Cell Senescence on Kidney Allograft Survival

The biological processes responsible for somatic cell senescence contribute to organ aging and progression of chronic diseases, and this may contribute to kidney transplant outcomes. We examined the effect of pre‐existing donor aging on the performance of kidney transplants, comparing mouse kidney i...

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Veröffentlicht in:	American journal of transplantation 2009-01, Vol.9 (1), p.114-123
Hauptverfasser:	Melk, A., Schmidt, B. M. W., Braun, H., Vongwiwatana, A., Urmson, J., Zhu, L.‐F., Rayner, D., Halloran, P. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - immunology Animals Biological and medical sciences Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 - genetics Donor age Graft Survival Immunohistochemistry Kidney - metabolism Kidney - pathology kidney aging Kidney Transplantation - immunology Male Medical sciences Mice Mice, Inbred CBA p16INK4a expression Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics senescence Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases transplantation Transplantation, Homologous
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