Novel single nucleotide polymorphisms and haplotypes within the bovine CXCR2 gene

Novel single nucleotide polymorphisms and haplotypes within the bovine CXCR2 gene

The objectives of this study were to identify single nucleotide polymorphisms (SNPs) and resulting haplotypes in the bovine CXCR2 gene. A 311-bp segment of the bovine CXCR2 gene was amplified and sequenced. Five SNPs at positions 612, 684, 777, 858, and 861 were expressed in both Holstein and Jersey...

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Veröffentlicht in:Immunogenetics (New York) 2004-08, Vol.56 (5), p.355-359
Hauptverfasser: Youngerman, S M, Saxton, A M, Pighetti, G M
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Animals
Cattle
Dairy cattle
Gene Frequency
Genes
Genetics
Haplotypes
Haplotypes - genetics
Polymorphism, Single Nucleotide
Receptors, Interleukin-8B - genetics
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Zusammenfassung:The objectives of this study were to identify single nucleotide polymorphisms (SNPs) and resulting haplotypes in the bovine CXCR2 gene. A 311-bp segment of the bovine CXCR2 gene was amplified and sequenced. Five SNPs at positions 612, 684, 777, 858, and 861 were expressed in both Holstein and Jersey dairy cattle. Four SNPs resulted in synonymous substitutions, while a non-synonymous switch at position 777 (G-->C) resulted in a glutamine to histidine substitution at amino acid residue 245. Strong linkage disequilibrium was exhibited for both breeds among all five loci (P
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-004-0699-5