Amphotericin B removal by plasma exchange

Summary This case report adds pharmacokinetic knowledge regarding amphotericin B. Amphotericin B is highly protein bound. Plasma exchange removes 50–75% of a substance in plasma within 1–2 h, corresponding to an elimination half‐life of 30–40 min. Amphotericin B reduction ratio by plasma exchange wa...

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Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2009-02, Vol.34 (1), p.115-117
1. Verfasser:	Lew, S. Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult amphotericin B Amphotericin B - blood Antifungal Agents - blood Biological and medical sciences Half-Life Humans Injections, Intravenous Liver Failure - metabolism Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure pharmacokinetics Pharmacology. Drug treatments Plasma Exchange plasmapheresis Protein Binding protein bound Purpura, Thrombotic Thrombocytopenic - metabolism Purpura, Thrombotic Thrombocytopenic - therapy Renal Dialysis Renal failure Renal Insufficiency - metabolism
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Beschreibung
Zusammenfassung:	Summary This case report adds pharmacokinetic knowledge regarding amphotericin B. Amphotericin B is highly protein bound. Plasma exchange removes 50–75% of a substance in plasma within 1–2 h, corresponding to an elimination half‐life of 30–40 min. Amphotericin B reduction ratio by plasma exchange was 40% in this patient who had both liver and renal failure.
ISSN:	0269-4727 1365-2710
DOI:	10.1111/j.1365-2710.2008.00964.x