From chromatin to cancer: a new histone lysine methyltransferase enters the mix

Disruption of post-translational modifications of histone proteins perturbs the proper pattern of gene expression and has the potential to result in diseases, such as cancer. A study implicating a new histone lysine methyltransferase in tumorigenesis further corroborates the emerging link between ca...

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Veröffentlicht in:	Nature cell biology 2004-08, Vol.6 (8), p.685-687
Hauptverfasser:	Sims, Robert J., Reinberg, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biomedical and Life Sciences Cancer Research Carcinoma - enzymology Carcinoma - pathology Cell Biology Chromatin Chromatin - metabolism Developmental Biology DNA Methylation Gene Expression Regulation Genetic aspects Genetic transcription Histone-Lysine N-Methyltransferase - chemistry Histone-Lysine N-Methyltransferase - metabolism Life Sciences Methyltransferases Models, Biological Neoplasms - enzymology Neoplasms - pathology news-and-views Physiological aspects Protein Processing, Post-Translational Protein Structure, Tertiary Stem Cells
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Zusammenfassung:	Disruption of post-translational modifications of histone proteins perturbs the proper pattern of gene expression and has the potential to result in diseases, such as cancer. A study implicating a new histone lysine methyltransferase in tumorigenesis further corroborates the emerging link between cancer and epigenetics.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/ncb0804-685