In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis
Summary The minimum inhibitory concentrations (MIC, μg ml−1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38‐P microdilution method suggested by National Committee for Clinical Laboratory Standards (NC...
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| Veröffentlicht in: | Mycoses 2004-08, Vol.47 (7), p.284-287 |
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| creator | Karaarslan, A. Arikan, S. Ozcan, M. Ozcan, K. M. |
| description | Summary
The minimum inhibitory concentrations (MIC, μg ml−1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38‐P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC‐2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC‐0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125–1 and 0.06–0.5 μg ml−1 for A. niger (22 strains), 0.06–0.25 and 0.06–0.125 μg ml−1 for A. flavus (10 strains), 0.125 and 0.125–0.5 μg ml−1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.
Zusammenfassung
An 34 Aspergillus‐Stämmen, isoliert bei Otitis externa, wurde die minimale Hemmkonzentration (MHK) für Itraconazol und Terbinafin bestimmt. Beide Medikamente zeigten In vitro‐Aktivität gegen alle Aspergillus‐Isolate. |
| doi_str_mv | 10.1111/j.1439-0507.2004.00988.x |
| format | Article |
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The minimum inhibitory concentrations (MIC, μg ml−1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38‐P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC‐2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC‐0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125–1 and 0.06–0.5 μg ml−1 for A. niger (22 strains), 0.06–0.25 and 0.06–0.125 μg ml−1 for A. flavus (10 strains), 0.125 and 0.125–0.5 μg ml−1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.
Zusammenfassung
An 34 Aspergillus‐Stämmen, isoliert bei Otitis externa, wurde die minimale Hemmkonzentration (MHK) für Itraconazol und Terbinafin bestimmt. Beide Medikamente zeigten In vitro‐Aktivität gegen alle Aspergillus‐Isolate.</description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1111/j.1439-0507.2004.00988.x</identifier><identifier>PMID: 15310330</identifier><language>eng</language><publisher>Berling, Germany: Blackwell Verlag, GmbH</publisher><subject>Antifungal Agents - pharmacology ; antifungal susceptibility ; Aspergillus ; Aspergillus - classification ; Aspergillus - drug effects ; Aspergillus - isolation & purification ; Ear Canal - microbiology ; Ear Diseases - microbiology ; Empfindlichkeit ; Humans ; Itraconazol ; itraconazole ; Itraconazole - pharmacology ; Microbial Sensitivity Tests ; Mycoses - microbiology ; Naphthalenes - pharmacology ; otomycosis ; Otomykose ; Terbinafin ; terbinafine</subject><ispartof>Mycoses, 2004-08, Vol.47 (7), p.284-287</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4338-44deaa09d16acc706717ec8e034a24cd185095b03edbad60e997cb41b7d82e4f3</citedby><cites>FETCH-LOGICAL-c4338-44deaa09d16acc706717ec8e034a24cd185095b03edbad60e997cb41b7d82e4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0507.2004.00988.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0507.2004.00988.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15310330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karaarslan, A.</creatorcontrib><creatorcontrib>Arikan, S.</creatorcontrib><creatorcontrib>Ozcan, M.</creatorcontrib><creatorcontrib>Ozcan, K. M.</creatorcontrib><title>In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description>Summary
The minimum inhibitory concentrations (MIC, μg ml−1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38‐P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC‐2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC‐0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125–1 and 0.06–0.5 μg ml−1 for A. niger (22 strains), 0.06–0.25 and 0.06–0.125 μg ml−1 for A. flavus (10 strains), 0.125 and 0.125–0.5 μg ml−1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.
Zusammenfassung
An 34 Aspergillus‐Stämmen, isoliert bei Otitis externa, wurde die minimale Hemmkonzentration (MHK) für Itraconazol und Terbinafin bestimmt. Beide Medikamente zeigten In vitro‐Aktivität gegen alle Aspergillus‐Isolate.</description><subject>Antifungal Agents - pharmacology</subject><subject>antifungal susceptibility</subject><subject>Aspergillus</subject><subject>Aspergillus - classification</subject><subject>Aspergillus - drug effects</subject><subject>Aspergillus - isolation & purification</subject><subject>Ear Canal - microbiology</subject><subject>Ear Diseases - microbiology</subject><subject>Empfindlichkeit</subject><subject>Humans</subject><subject>Itraconazol</subject><subject>itraconazole</subject><subject>Itraconazole - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Mycoses - microbiology</subject><subject>Naphthalenes - pharmacology</subject><subject>otomycosis</subject><subject>Otomykose</subject><subject>Terbinafin</subject><subject>terbinafine</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVFv0zAUhS0EYmXwF5CfeEu4rh3bkXiZKhiTyiamQcWT5Tg3k0sSFzuFll-PS6vxyPziI_s790rnEEIZlCyft-uSCV4XUIEq5wCiBKi1LndPyOzh4ymZQc15oQSoM_IipTUAU_VcPidnrOIMOIcZ6a5G-tNPMVDrJp_VnoaOThgbP9rOj0jt2NIMWBdG-zv0-eHe-jFN9CJtMN77vt8mmqXzmKhPobcTtrSLYaBhCsPeheTTS_Kss33CV6f7nHz58P5u8bFY3lxeLS6WhROc60KIFq2FumXSOqdAKqbQaQQu7Fy4lukK6qoBjm1jWwlY18o1gjWq1XMUHT8nb45zNzH82GKazOCTw763I4ZtMlIqLWsF_wWZhqriWmZQH0EXQ0oRO7OJfrBxbxiYQxlmbQ6Zm0Pm5lCG-VuG2WXr69OObTNg-894Sj8D747AL9_j_tGDzadviyyyvTjafZpw92C38buRiqvKrK4vjbpdstvPq69mxf8AgfKpig</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Karaarslan, A.</creator><creator>Arikan, S.</creator><creator>Ozcan, M.</creator><creator>Ozcan, K. M.</creator><general>Blackwell Verlag, GmbH</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis</title><author>Karaarslan, A. ; Arikan, S. ; Ozcan, M. ; Ozcan, K. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4338-44deaa09d16acc706717ec8e034a24cd185095b03edbad60e997cb41b7d82e4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antifungal Agents - pharmacology</topic><topic>antifungal susceptibility</topic><topic>Aspergillus</topic><topic>Aspergillus - classification</topic><topic>Aspergillus - drug effects</topic><topic>Aspergillus - isolation & purification</topic><topic>Ear Canal - microbiology</topic><topic>Ear Diseases - microbiology</topic><topic>Empfindlichkeit</topic><topic>Humans</topic><topic>Itraconazol</topic><topic>itraconazole</topic><topic>Itraconazole - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Mycoses - microbiology</topic><topic>Naphthalenes - pharmacology</topic><topic>otomycosis</topic><topic>Otomykose</topic><topic>Terbinafin</topic><topic>terbinafine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karaarslan, A.</creatorcontrib><creatorcontrib>Arikan, S.</creatorcontrib><creatorcontrib>Ozcan, M.</creatorcontrib><creatorcontrib>Ozcan, K. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karaarslan, A.</au><au>Arikan, S.</au><au>Ozcan, M.</au><au>Ozcan, K. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2004-08</date><risdate>2004</risdate><volume>47</volume><issue>7</issue><spage>284</spage><epage>287</epage><pages>284-287</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract>Summary
The minimum inhibitory concentrations (MIC, μg ml−1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38‐P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC‐2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC‐0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125–1 and 0.06–0.5 μg ml−1 for A. niger (22 strains), 0.06–0.25 and 0.06–0.125 μg ml−1 for A. flavus (10 strains), 0.125 and 0.125–0.5 μg ml−1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.
Zusammenfassung
An 34 Aspergillus‐Stämmen, isoliert bei Otitis externa, wurde die minimale Hemmkonzentration (MHK) für Itraconazol und Terbinafin bestimmt. Beide Medikamente zeigten In vitro‐Aktivität gegen alle Aspergillus‐Isolate.</abstract><cop>Berling, Germany</cop><pub>Blackwell Verlag, GmbH</pub><pmid>15310330</pmid><doi>10.1111/j.1439-0507.2004.00988.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Antifungal Agents - pharmacology antifungal susceptibility Aspergillus Aspergillus - classification Aspergillus - drug effects Aspergillus - isolation & purification Ear Canal - microbiology Ear Diseases - microbiology Empfindlichkeit Humans Itraconazol itraconazole Itraconazole - pharmacology Microbial Sensitivity Tests Mycoses - microbiology Naphthalenes - pharmacology otomycosis Otomykose Terbinafin terbinafine |
| title | In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis |
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