In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis

Summary The minimum inhibitory concentrations (MIC, μg ml−1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38‐P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC‐2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC‐0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125–1 and 0.06–0.5 μg ml−1 for A. niger (22 strains), 0.06–0.25 and 0.06–0.125 μg ml−1 for A. flavus (10 strains), 0.125 and 0.125–0.5 μg ml−1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested. Zusammenfassung An 34 Aspergillus‐Stämmen, isoliert bei Otitis externa, wurde die minimale Hemmkonzentration (MHK) für Itraconazol und Terbinafin bestimmt. Beide Medikamente zeigten In vitro‐Aktivität gegen alle Aspergillus‐Isolate.