Quantitative Effects of Palivizumab and Donor-Derived T Cells on Chronic Respiratory Syncytial Virus Infection, Lung Disease, and Fusion Glycoprotein Amino Acid Sequences in a Patient Before and After Bone Marrow Transplantation

A patient with respiratory syncytial virus (RSV) infection and severe combined immunodeficiency was studied during a 3-month period of bone marrow transplantation and palivizumab infusion. No RSV isolates with palivizumab escape mutations were identified. Donor lymphocytes, including CD8 cells, appe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical infectious diseases 2004-07, Vol.39 (2), p.e17-e20
Hauptverfasser:	El Saleeby, C. M., Suzich, J., Conley, M. E., DeVincenzo, J. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Bone Marrow Transplantation - immunology Humans Immunoglobulins, Intravenous - therapeutic use Immunosuppressive Agents - therapeutic use Infant Lymphocyte Count Male Palivizumab Pneumonia, Viral - immunology Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - therapy Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus, Human - immunology Severe Combined Immunodeficiency - complications Severe Combined Immunodeficiency - therapy T-Lymphocytes - physiology Viral Fusion Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A patient with respiratory syncytial virus (RSV) infection and severe combined immunodeficiency was studied during a 3-month period of bone marrow transplantation and palivizumab infusion. No RSV isolates with palivizumab escape mutations were identified. Donor lymphocytes, including CD8 cells, appeared to markedly reduce the RSV load but increased the pulmonary symptoms. Immunosuppressive therapy ameliorated lung disease but allowed the RSV load to rebound.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/421779