Hollow Manganese Oxide Nanoparticles as Multifunctional Agents for Magnetic Resonance Imaging and Drug Delivery

MRI jack‐o'‐lanterns? Hollow manganese oxide nanoparticles (HMON) show greatly improved relaxivities and drug‐loading capacities compared to those with solid interiors (WMON). Their efficient cellular uptake demonstrates their potential as a bifunctional medical system that combines diagnostic...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-01, Vol.48 (2), p.321-324
Hauptverfasser:	Shin, Jongmin, Anisur, Rahman Md, Ko, Mi Kyeong, Im, Geun Ho, Lee, Jung Hee, Lee, In Su
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - anatomy & histology Cell Line, Tumor Cell Proliferation - drug effects contrast agents Contrast Media - chemical synthesis Contrast Media - chemistry Contrast Media - pharmacology Dose-Response Relationship, Drug drug delivery Drug Delivery Systems Drug Screening Assays, Antitumor Magnetic Resonance Imaging manganese Manganese Compounds - chemical synthesis Manganese Compounds - chemistry Manganese Compounds - pharmacology Mice Microscopy, Electron, Scanning Microscopy, Electron, Transmission nanoparticles Nanoparticles - chemistry Oleic Acid - chemistry Oxides - chemical synthesis Oxides - chemistry Oxides - pharmacology Particle Size Porosity Powder Diffraction Sensitivity and Specificity Spectrophotometry Surface Properties X-Rays
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Beschreibung
Zusammenfassung:	MRI jack‐o'‐lanterns? Hollow manganese oxide nanoparticles (HMON) show greatly improved relaxivities and drug‐loading capacities compared to those with solid interiors (WMON). Their efficient cellular uptake demonstrates their potential as a bifunctional medical system that combines diagnostic imaging and targeted therapy.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200802323