Effective Binding and Sensing of Lipopolysaccharide: Combining Complementary Pattern Recognition Receptors

Effective Binding and Sensing of Lipopolysaccharide: Combining Complementary Pattern Recognition Receptors

Nature inspired: A synthetic receptor (see picture) that exploits two zinc(II) ions and four convergent amino hydrogen bonding groups binds lipopolysaccharides (LPSs) almost as strongly as the LPS binding protein. This feature is exploited to electrochemically distinguish LPS from other pathogens in...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (2), p.356-360
Hauptverfasser: Ganesh, V, Bodewits, Karin, Bartholdson, S. Josefin, Natale, Daniela, Campopiano, Dominic J, Mareque-Rivas, Juan C
Format: Artikel
Sprache:eng
Schlagworte:
anion receptors
Binding Sites
dinuclear complexes
Hydrogen Bonding
lipopolysaccharides
Lipopolysaccharides - analysis
Lipopolysaccharides - chemistry
Models, Molecular
molecular recognition
Molecular Structure
Organometallic Compounds - chemistry
Polymyxin B - chemistry
Receptors, Pattern Recognition - chemistry
sensors
Zinc - chemistry
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Zusammenfassung:Nature inspired: A synthetic receptor (see picture) that exploits two zinc(II) ions and four convergent amino hydrogen bonding groups binds lipopolysaccharides (LPSs) almost as strongly as the LPS binding protein. This feature is exploited to electrochemically distinguish LPS from other pathogens in water and in complex biological mixtures. Zn pink, N blue, P orange, O red.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200804168