Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk

Abstract An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control sub...

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Veröffentlicht in:	Neurobiology of aging 2009-02, Vol.30 (2), p.322-324
Hauptverfasser:	Rodríguez-Rodríguez, Eloy, Infante, Jon, Llorca, Javier, Mateo, Ignacio, Sánchez-Quintana, Coro, García-Gorostiaga, Inés, Sánchez-Juan, Pascual, Berciano, José, Combarros, Onofre
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - genetics Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Development. Senescence. Regeneration. Transplantation Episodic memory Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genetic Variation - genetics Humans Incidence Internal Medicine Intracellular Signaling Peptides and Proteins KIBRA Male Medical sciences Middle Aged Neurology Phosphoproteins Polymorphism Polymorphism, Single Nucleotide - genetics Proteins - genetics Risk Assessment - methods Risk Factors Spain - epidemiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Abstract An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p = 0.03) for very-late-onset (after the age of 86 years) AD.
ISSN:	0197-4580 1558-1497
DOI:	10.1016/j.neurobiolaging.2007.07.003