Renin, Cyclooxygenase-2 and Neuronal Nitric Oxide Synthase in the Kidneys of Transgenic Tsukuba Hypertensive Mouse

The transgenic Tsukuba hypertensive mouse (THM), which expresses the human renin and angiotensinogen genes, develops hypertension secondary to increased renin-angiotensin system activity. The aim of the present study was to assess expression of the renin, cyclooxygenase-2 (COX-2), and neuronal nitri...

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Veröffentlicht in:	Experimental Animals 2004, Vol.53(4), pp.387-390
Hauptverfasser:	YABUKI, Akira, MATSUMOTO, Mitsuharu, KAMIMURA, Ryozo, TANIGUCHI, Kazuyuki, SUZUKI, Syusaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclooxygenase 2 Disease Models, Animal Hypertension - enzymology Immunohistochemistry Isoenzymes - analysis Kidney - enzymology Mice Mice, Transgenic Nitric Oxide Synthase - analysis Nitric Oxide Synthase Type I Prostaglandin-Endoperoxide Synthases - analysis renin Renin - analysis transgenic Tsukuba hypertensive mouse
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Zusammenfassung:	The transgenic Tsukuba hypertensive mouse (THM), which expresses the human renin and angiotensinogen genes, develops hypertension secondary to increased renin-angiotensin system activity. The aim of the present study was to assess expression of the renin, cyclooxygenase-2 (COX-2), and neuronal nitric oxide synthase (nNOS) proteins in THM kidneys by immunohistochemical stainings. Renin expression was decreased in the THM kidneys when compared to kidneys from heterozygotes or control mice. Although no differences were observed in nNOS expression, overexpression of the COX-2 protein was observed in the macula densa cells in THM kidneys.
ISSN:	1341-1357 1881-7122
DOI:	10.1538/expanim.53.387