Mononucleotide markers of microsatellite instability in carcinomas of the urinary bladder

Aims. To determine the presence of microsatellite instability (MSI) and to assess the expression of the human mismatch repair (MMR) gene products hMLH1 and hMSH2 in primary transitional cell carcinomas (TCCs) of the urinary bladder in relation to clinico-pathological parameters. Methods. Seventy-two...

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Veröffentlicht in:	European journal of surgical oncology 2004-09, Vol.30 (7), p.796-803
Hauptverfasser:	Saetta, A.A, Goudopoulou, A, Korkolopoulou, P, Voutsinas, G, Thomas-Tsagli, E, Michalopoulos, N.V, Patsouris, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Aged, 80 and over BAT-26 Biomarkers, Tumor - genetics Bladder cancer Carcinoma, Transitional Cell - genetics Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Carrier Proteins Disease-Free Survival DNA-Binding Proteins - genetics Female Gene Expression Regulation, Neoplastic Greece - epidemiology Humans Immunohistochemistry Male Medical Records Microsatellite Repeats - genetics Middle Aged MMR MSI MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - genetics Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Staging Nuclear Proteins PCR Predictive Value of Tests Proto-Oncogene Proteins - genetics Retrospective Studies Survival Analysis TGF-β RII Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology
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Zusammenfassung:	Aims. To determine the presence of microsatellite instability (MSI) and to assess the expression of the human mismatch repair (MMR) gene products hMLH1 and hMSH2 in primary transitional cell carcinomas (TCCs) of the urinary bladder in relation to clinico-pathological parameters. Methods. Seventy-two cases of primary TCC were screened for the presence of alterations in MSI markers by molecular techniques and evaluated immunohistochemically for the expression of hMLH1 and hMSH2 proteins. Clinical data were available in 70 cases. The percentage of MSI rose to 16.6%. Results. Reduced (
ISSN:	0748-7983 1532-2157
DOI:	10.1016/j.ejso.2004.04.015