3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

New isoquinoline-based non-nucleoside inhibitors ( 2, 3) of HCV NS5b RNA-dependent RNA-polymerase are described. Their syntheses and structure–activity relationships are detailed, along with enzyme and cellular activities. Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-po...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-01, Vol.19 (2), p.410-414
Hauptverfasser:	Hendricks, Robert T., Spencer, Stacey R., Blake, James F., Fell, Jay B., Fischer, John P., Stengel, Peter J., Leveque, Vincent J.P., LePogam, Sophie, Rajyaguru, Sonal, Najera, Isabel, Josey, John A., Swallow, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminobenzenesulfonamide 3-Carbomethoxy-1,2,3,4-tetrahydroisoquinoline-1,4-dione 3-Hydroxyisoquinoline Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Computational Conformation Dioxo-benzoisothiazole Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Gamess HCV Hepatitis Hepatitis C virus Inhibitor Isoquinoline Isoquinolines - chemistry Isoquinolines - pharmacology Medical sciences Models, Molecular N- tert-Butyl-2-chlorobenzene-sulfonamide Negishi Non-nucleoside NS5b Palm Pharmacology. Drug treatments Polymerase rdrp Replicon RNA-Dependent RNA Polymerase - antagonists & inhibitors Structure-Activity Relationship Suzuki Viral Nonstructural Proteins - antagonists & inhibitors
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Zusammenfassung:	New isoquinoline-based non-nucleoside inhibitors ( 2, 3) of HCV NS5b RNA-dependent RNA-polymerase are described. Their syntheses and structure–activity relationships are detailed, along with enzyme and cellular activities. Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure–activity relationships are detailed, along with enzyme and cellular activity.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2008.11.060