A DNA-Based Machine That Can Cyclically Bind and Release Thrombin

A DNA-Based Machine That Can Cyclically Bind and Release Thrombin

A DNA aptamer structure is the basis of a molecular machine that can be instructed to grab or release the human blood‐clotting factor α‐thrombin, depending on the operator DNA sequence addressing it. In the picture the aptamer structure, which assumes a conformation characterized by two stacked guan...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-07, Vol.43 (27), p.3550-3553
Hauptverfasser: Dittmer, Wendy U., Reuter, Andreas, Simmel, Friedrich C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
aptamers
Base Sequence
DNA
DNA - metabolism
DNA structures
molecular devices
Molecular Sequence Data
nanostructures
Nanotechnology
Oligodeoxyribonucleotides - chemistry
Oligodeoxyribonucleotides - metabolism
Thrombin - metabolism
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Beschreibung
Zusammenfassung:A DNA aptamer structure is the basis of a molecular machine that can be instructed to grab or release the human blood‐clotting factor α‐thrombin, depending on the operator DNA sequence addressing it. In the picture the aptamer structure, which assumes a conformation characterized by two stacked guanine quadruplex structures, is linked to thrombin (gray ellipse).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200353537