Hepatitis B virus-specific T cell response in chronic hepatitis B patients treated with lamivudine and interferon-α

: Aims: The goal of the present study was to assess the impact combination antiviral therapy has on immune responses in chronic hepatitis B. Materials and methods: T cell responses were studied in 16 chronically hepatitis B virus (HBV)‐infected patients treated with sequential, partially overlapping...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Liver international 2004-08, Vol.24 (4), p.308-315
Hauptverfasser:	Pontesilli, Oscar, Van Nunen, Andeltje B., Van Riel, Debby, Carotenuto, Patrizia, Niesters, Hubert G., Uytdehaag, Fons G., De Man, Robert A., Osterhaus, Albert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents - administration & dosage antiviral immunity antiviral therapy DNA, Viral - blood Drug Therapy, Combination HBV Hepatitis B Core Antigens - blood Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - immunology Humans Interferon-alpha - administration & dosage interferon-α lamivudine Lamivudine - administration & dosage lymphoproliferative response Middle Aged Pilot Projects Reverse Transcriptase Inhibitors - administration & dosage T-Lymphocytes - immunology T-Lymphocytes - virology Viral Load Virus Replication - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	: Aims: The goal of the present study was to assess the impact combination antiviral therapy has on immune responses in chronic hepatitis B. Materials and methods: T cell responses were studied in 16 chronically hepatitis B virus (HBV)‐infected patients treated with sequential, partially overlapping, lamivudine‐interferon (IFN)‐α combination therapy. Results: HBcAg‐specific lymphoproliferative response (LPR) was transiently detected in four of five patients who achieved virus suppression (HBV DNA
ISSN:	1478-3223 1478-3231
DOI:	10.1111/j.1478-3231.2004.0922.x