Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues
Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2004-08, Vol.89 (8), p.4119-4123 |
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| container_issue | 8 |
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| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 89 |
| creator | Carlson, Harold E. Kane, Philip Lei, Z. M. Li, X. Rao, C. V. |
| description | Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders. |
| doi_str_mv | 10.1210/jc.2003-031882 |
| format | Article |
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Psychology ; Gynecomastia - metabolism ; Gynecomastia - pathology ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Male ; Medical sciences ; Middle Aged ; Receptors, LH - genetics ; Receptors, LH - metabolism ; RNA, Messenger - metabolism ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2004-08, Vol.89 (8), p.4119-4123</ispartof><rights>Copyright © Oxford University Press 2015</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4529-954f0b166733fadfc4382f6446c2cb9bbb48b3743d92543a7326b13dc4700b533</citedby><cites>FETCH-LOGICAL-c4529-954f0b166733fadfc4382f6446c2cb9bbb48b3743d92543a7326b13dc4700b533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16006769$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15292356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlson, Harold E.</creatorcontrib><creatorcontrib>Kane, Philip</creatorcontrib><creatorcontrib>Lei, Z. M.</creatorcontrib><creatorcontrib>Li, X.</creatorcontrib><creatorcontrib>Rao, C. V.</creatorcontrib><title>Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast - metabolism</subject><subject>Breast Neoplasms, Male - metabolism</subject><subject>Case-Control Studies</subject><subject>Endocrinopathies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gynecomastia - metabolism</subject><subject>Gynecomastia - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, LH - genetics</subject><subject>Receptors, LH - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-L1DAcxYMo7rh69Si56K2z-dWkPeqgO8KIIit4kZCk3zoZ26QmLYv-9WbowJ4MhPCFz3vvywtCLynZUkbJzcltGSG8Ipw2DXuENrQVdaVoqx6jDSGMVq1i36_Qs5xPhFAhav4UXdGatYzXcoN-fEmQITjAsceHZQYf_F8ffuJ9TGMMcLNfRhPw7hiTj8E7fBuD6eKc4uQD_goOpjmmjMvwyQyA3yUwecZ3PucF8nP0pDdDhheX9xp9-_D-brevDp9vP-7eHionyiZVW4ueWCql4rw3Xe8Eb1gvhZCOOdtaa0VjuRK8a1ktuFGcSUt554QixNacX6M3q--U4u-SO-vRZwfDYALEJeviLJUiZ3C7gi7FnBP0ekp-NOmPpkSfC9Unp8-F6rXQInh1cV7sCN0DfmmwAK8vgMnODH0ywfn8wElCSnhbOLFy93GYIeVfw3IPSR_BDPNRk3KEVE1VsgVpylSVq86yepVB6KJLPsBUPizrU1xSKJX-b-9_NOueqw</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Carlson, Harold E.</creator><creator>Kane, Philip</creator><creator>Lei, Z. 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Psychology</topic><topic>Gynecomastia - metabolism</topic><topic>Gynecomastia - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, LH - genetics</topic><topic>Receptors, LH - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlson, Harold E.</creatorcontrib><creatorcontrib>Kane, Philip</creatorcontrib><creatorcontrib>Lei, Z. M.</creatorcontrib><creatorcontrib>Li, X.</creatorcontrib><creatorcontrib>Rao, C. 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V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2004-08</date><risdate>2004</risdate><volume>89</volume><issue>8</issue><spage>4119</spage><epage>4123</epage><pages>4119-4123</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>15292356</pmid><doi>10.1210/jc.2003-031882</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2004-08, Vol.89 (8), p.4119-4123 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Breast - metabolism Breast Neoplasms, Male - metabolism Case-Control Studies Endocrinopathies Fundamental and applied biological sciences. Psychology Gynecomastia - metabolism Gynecomastia - pathology Humans Immunohistochemistry In Situ Hybridization Male Medical sciences Middle Aged Receptors, LH - genetics Receptors, LH - metabolism RNA, Messenger - metabolism Vertebrates: endocrinology |
| title | Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues |
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