Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues

Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2004-08, Vol.89 (8), p.4119-4123
Hauptverfasser: Carlson, Harold E., Kane, Philip, Lei, Z. M., Li, X., Rao, C. V.
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Sprache:eng
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Zusammenfassung:Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2003-031882