Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues
Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy...
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Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2004-08, Vol.89 (8), p.4119-4123 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders. |
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ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/jc.2003-031882 |