Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: A 25-year experience

Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: A 25-year experience

To analyze the outcome of children with short bowel syndrome (SBS) who required long-term parenteral nutrition (PN). Retrospective analysis of children (n = 78) with SBS who required PN >3 months from 1975 to 2000. Statistics: univariate analysis, Kaplan-Meier method, and Cox proportional regress...

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Veröffentlicht in:The Journal of pediatrics 2004-08, Vol.145 (2), p.157-163
Hauptverfasser: Quirós-Tejeira, Rubén E., Ament, Marvin E., Reyen, Laurie, Herzog, Faye, Merjanian, Michelle, Olivares-Serrano, Nancy, Vargas, Jorge H.
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Physiological
Biological and medical sciences
Child, Preschool
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Infant
Male
Medical sciences
Other diseases. Semiology
Parenteral Nutrition
Retrospective Studies
Short Bowel Syndrome - therapy
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Time Factors
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Zusammenfassung:To analyze the outcome of children with short bowel syndrome (SBS) who required long-term parenteral nutrition (PN). Retrospective analysis of children (n = 78) with SBS who required PN >3 months from 1975 to 2000. Statistics: univariate analysis, Kaplan-Meier method, and Cox proportional regression model were used. We identified 78 patients. Survival was better with small bowel length (SBL) >38 cm, intact ileocecal valve (ICV), intact colon, takedown surgery after ostomy (all P < .01), and primary anastomosis ( P < .001). PN-associated early persistent cholestatic jaundice ( P < .001) and SBL of
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2004.02.030