Omeprazole is more effective than famotidine for preventing acute gastritis in rats
Acute gastric mucosal lesions, which can develop within a few hours after polytrauma, shock, major operations, central nervous system lesions, or severe infection, cause about 33% of cases of gastrointestinal bleeding. We analyzed and compared the effectiveness of famotidine and omeprazole on acute...
Gespeichert in:
| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2004-08, Vol.34 (8), p.690-694 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 694 |
|---|---|
| container_issue | 8 |
| container_start_page | 690 |
| container_title | Surgery today (Tokyo, Japan) |
| container_volume | 34 |
| creator | Topaloglu, Umit Muftuoglu, Tolga Akturk, Zekeriya Ekinci, Huseyin Peker, Onder Unalmiser, Selcuk |
| description | Acute gastric mucosal lesions, which can develop within a few hours after polytrauma, shock, major operations, central nervous system lesions, or severe infection, cause about 33% of cases of gastrointestinal bleeding. We analyzed and compared the effectiveness of famotidine and omeprazole on acute gastric mucosal lesions.
Thirty male albino Wistar rats were given ketalar anesthesia after 12 h fasting, then immobilized and exposed to stress according to Brodie's protocol, without restricting their respiration. We divided the rats into three groups of ten according to whether they were given famotidine, omeprazole, or normal saline (control group). All rats were ulcer-indexed according to the diameter of their ulcers. The stomach contents were aspirated for acid output and pH analysis, and sent to the laboratory. The total number of mast cells was also counted.
Omeprazole was more effective than famotidine in keeping gastric pH high and lowering the total gastric acid output. Lower ulcer indexes in acute gastric mucosal erosions and better protected mucosal integrity were found in the omeprazole-treated rats.
Omeprazole prevents acute gastric mucosal erosions in rats more effectively than famotidine. |
| doi_str_mv | 10.1007/s00595-004-2800-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66765381</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66765381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-4a346c958aa9db4a0280666ebd9efdcae09a727cfb3a909d5194a5b0d5b1dd6c3</originalsourceid><addsrcrecordid>eNpFkE1LAzEURYMotlZ_gBvJyt3oy0ySNkspfkGhC3Ud3iRvaqQzU5NUqL_eKS24ely458I7jF0LuBMA0_sEoIwqAGRRzgCK3QkbC1npIYnqlI3BSFGI0ogRu0jpC6CUQ-2cjYQqDUiAMXtbtrSJ-NuviYfE2z4Sp6Yhl8MP8fyJHW-w7XPwoSPe9JFvIv1Ql0O34ui2mfgKU44hD3ToeMScLtlZg-tEV8c7YR9Pj-_zl2KxfH6dPywKJ5XJhcRKamfUDNH4WiIMP2itqfaGGu-QwOC0nLqmrtCA8UoYiaoGr2rhvXbVhN0edjex_95SyrYNydF6jR3122S1nmpVDSomTByKLvYpRWrsJoYW484KsHuT9mDSDibt3qTdDczNcXxbt-T_iaO66g88B3Cu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66765381</pqid></control><display><type>article</type><title>Omeprazole is more effective than famotidine for preventing acute gastritis in rats</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Topaloglu, Umit ; Muftuoglu, Tolga ; Akturk, Zekeriya ; Ekinci, Huseyin ; Peker, Onder ; Unalmiser, Selcuk</creator><creatorcontrib>Topaloglu, Umit ; Muftuoglu, Tolga ; Akturk, Zekeriya ; Ekinci, Huseyin ; Peker, Onder ; Unalmiser, Selcuk</creatorcontrib><description>Acute gastric mucosal lesions, which can develop within a few hours after polytrauma, shock, major operations, central nervous system lesions, or severe infection, cause about 33% of cases of gastrointestinal bleeding. We analyzed and compared the effectiveness of famotidine and omeprazole on acute gastric mucosal lesions.
Thirty male albino Wistar rats were given ketalar anesthesia after 12 h fasting, then immobilized and exposed to stress according to Brodie's protocol, without restricting their respiration. We divided the rats into three groups of ten according to whether they were given famotidine, omeprazole, or normal saline (control group). All rats were ulcer-indexed according to the diameter of their ulcers. The stomach contents were aspirated for acid output and pH analysis, and sent to the laboratory. The total number of mast cells was also counted.
Omeprazole was more effective than famotidine in keeping gastric pH high and lowering the total gastric acid output. Lower ulcer indexes in acute gastric mucosal erosions and better protected mucosal integrity were found in the omeprazole-treated rats.
Omeprazole prevents acute gastric mucosal erosions in rats more effectively than famotidine.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-004-2800-y</identifier><identifier>PMID: 15290400</identifier><language>eng</language><publisher>Japan</publisher><subject>Animals ; Anti-Ulcer Agents - therapeutic use ; Cell Count ; Famotidine - therapeutic use ; Gastric Acid - secretion ; Gastric Mucosa - drug effects ; Gastritis - prevention & control ; Hydrogen-Ion Concentration ; Male ; Mast Cells - pathology ; Omeprazole - therapeutic use ; Premedication ; Rats ; Rats, Wistar ; Stomach Ulcer - prevention & control ; Stress, Physiological - pathology</subject><ispartof>Surgery today (Tokyo, Japan), 2004-08, Vol.34 (8), p.690-694</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-4a346c958aa9db4a0280666ebd9efdcae09a727cfb3a909d5194a5b0d5b1dd6c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15290400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Topaloglu, Umit</creatorcontrib><creatorcontrib>Muftuoglu, Tolga</creatorcontrib><creatorcontrib>Akturk, Zekeriya</creatorcontrib><creatorcontrib>Ekinci, Huseyin</creatorcontrib><creatorcontrib>Peker, Onder</creatorcontrib><creatorcontrib>Unalmiser, Selcuk</creatorcontrib><title>Omeprazole is more effective than famotidine for preventing acute gastritis in rats</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><description>Acute gastric mucosal lesions, which can develop within a few hours after polytrauma, shock, major operations, central nervous system lesions, or severe infection, cause about 33% of cases of gastrointestinal bleeding. We analyzed and compared the effectiveness of famotidine and omeprazole on acute gastric mucosal lesions.
Thirty male albino Wistar rats were given ketalar anesthesia after 12 h fasting, then immobilized and exposed to stress according to Brodie's protocol, without restricting their respiration. We divided the rats into three groups of ten according to whether they were given famotidine, omeprazole, or normal saline (control group). All rats were ulcer-indexed according to the diameter of their ulcers. The stomach contents were aspirated for acid output and pH analysis, and sent to the laboratory. The total number of mast cells was also counted.
Omeprazole was more effective than famotidine in keeping gastric pH high and lowering the total gastric acid output. Lower ulcer indexes in acute gastric mucosal erosions and better protected mucosal integrity were found in the omeprazole-treated rats.
Omeprazole prevents acute gastric mucosal erosions in rats more effectively than famotidine.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Cell Count</subject><subject>Famotidine - therapeutic use</subject><subject>Gastric Acid - secretion</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastritis - prevention & control</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Mast Cells - pathology</subject><subject>Omeprazole - therapeutic use</subject><subject>Premedication</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stomach Ulcer - prevention & control</subject><subject>Stress, Physiological - pathology</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEURYMotlZ_gBvJyt3oy0ySNkspfkGhC3Ud3iRvaqQzU5NUqL_eKS24ely458I7jF0LuBMA0_sEoIwqAGRRzgCK3QkbC1npIYnqlI3BSFGI0ogRu0jpC6CUQ-2cjYQqDUiAMXtbtrSJ-NuviYfE2z4Sp6Yhl8MP8fyJHW-w7XPwoSPe9JFvIv1Ql0O34ui2mfgKU44hD3ToeMScLtlZg-tEV8c7YR9Pj-_zl2KxfH6dPywKJ5XJhcRKamfUDNH4WiIMP2itqfaGGu-QwOC0nLqmrtCA8UoYiaoGr2rhvXbVhN0edjex_95SyrYNydF6jR3122S1nmpVDSomTByKLvYpRWrsJoYW484KsHuT9mDSDibt3qTdDczNcXxbt-T_iaO66g88B3Cu</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Topaloglu, Umit</creator><creator>Muftuoglu, Tolga</creator><creator>Akturk, Zekeriya</creator><creator>Ekinci, Huseyin</creator><creator>Peker, Onder</creator><creator>Unalmiser, Selcuk</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040801</creationdate><title>Omeprazole is more effective than famotidine for preventing acute gastritis in rats</title><author>Topaloglu, Umit ; Muftuoglu, Tolga ; Akturk, Zekeriya ; Ekinci, Huseyin ; Peker, Onder ; Unalmiser, Selcuk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-4a346c958aa9db4a0280666ebd9efdcae09a727cfb3a909d5194a5b0d5b1dd6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Cell Count</topic><topic>Famotidine - therapeutic use</topic><topic>Gastric Acid - secretion</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastritis - prevention & control</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Mast Cells - pathology</topic><topic>Omeprazole - therapeutic use</topic><topic>Premedication</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stomach Ulcer - prevention & control</topic><topic>Stress, Physiological - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Topaloglu, Umit</creatorcontrib><creatorcontrib>Muftuoglu, Tolga</creatorcontrib><creatorcontrib>Akturk, Zekeriya</creatorcontrib><creatorcontrib>Ekinci, Huseyin</creatorcontrib><creatorcontrib>Peker, Onder</creatorcontrib><creatorcontrib>Unalmiser, Selcuk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Topaloglu, Umit</au><au>Muftuoglu, Tolga</au><au>Akturk, Zekeriya</au><au>Ekinci, Huseyin</au><au>Peker, Onder</au><au>Unalmiser, Selcuk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omeprazole is more effective than famotidine for preventing acute gastritis in rats</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><addtitle>Surg Today</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>34</volume><issue>8</issue><spage>690</spage><epage>694</epage><pages>690-694</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Acute gastric mucosal lesions, which can develop within a few hours after polytrauma, shock, major operations, central nervous system lesions, or severe infection, cause about 33% of cases of gastrointestinal bleeding. We analyzed and compared the effectiveness of famotidine and omeprazole on acute gastric mucosal lesions.
Thirty male albino Wistar rats were given ketalar anesthesia after 12 h fasting, then immobilized and exposed to stress according to Brodie's protocol, without restricting their respiration. We divided the rats into three groups of ten according to whether they were given famotidine, omeprazole, or normal saline (control group). All rats were ulcer-indexed according to the diameter of their ulcers. The stomach contents were aspirated for acid output and pH analysis, and sent to the laboratory. The total number of mast cells was also counted.
Omeprazole was more effective than famotidine in keeping gastric pH high and lowering the total gastric acid output. Lower ulcer indexes in acute gastric mucosal erosions and better protected mucosal integrity were found in the omeprazole-treated rats.
Omeprazole prevents acute gastric mucosal erosions in rats more effectively than famotidine.</abstract><cop>Japan</cop><pmid>15290400</pmid><doi>10.1007/s00595-004-2800-y</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2004-08, Vol.34 (8), p.690-694 |
| issn | 0941-1291 1436-2813 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66765381 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Anti-Ulcer Agents - therapeutic use Cell Count Famotidine - therapeutic use Gastric Acid - secretion Gastric Mucosa - drug effects Gastritis - prevention & control Hydrogen-Ion Concentration Male Mast Cells - pathology Omeprazole - therapeutic use Premedication Rats Rats, Wistar Stomach Ulcer - prevention & control Stress, Physiological - pathology |
| title | Omeprazole is more effective than famotidine for preventing acute gastritis in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T10%3A49%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Omeprazole%20is%20more%20effective%20than%20famotidine%20for%20preventing%20acute%20gastritis%20in%20rats&rft.jtitle=Surgery%20today%20(Tokyo,%20Japan)&rft.au=Topaloglu,%20Umit&rft.date=2004-08-01&rft.volume=34&rft.issue=8&rft.spage=690&rft.epage=694&rft.pages=690-694&rft.issn=0941-1291&rft.eissn=1436-2813&rft_id=info:doi/10.1007/s00595-004-2800-y&rft_dat=%3Cproquest_cross%3E66765381%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66765381&rft_id=info:pmid/15290400&rfr_iscdi=true |