The cardiovascular and renal effects of a highly potent μ-opioid receptor agonist, cyclo[ Nε, Nβ-carbonyl- d-Lys 2,Dap 5]enkephalinamide

Investigation of the acute cardiovascular and renal effects of cyclo[ N ε, N β-carbonyl- d-Lys 2,Dap 5]enkephalinamide (cUENK6), the most potent μ-opioid receptor agonist, revealed dose-related effects, but most pronounced during the first hour post i.v. injections. During first hour, cUENK6 (3 μg/r...

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Veröffentlicht in:	European journal of pharmacology 2004-08, Vol.496 (1), p.167-174
Hauptverfasser:	Gutkowska, Jolanta, Jankowski, Marek, Pawlak, Danuta, Mukaddam-Daher, Suhayla, Izdebski, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Diuresis Dose-Response Relationship, Drug Enkephalin analogue cUENK6 Enkephalins - pharmacology Heart Rate - drug effects Heart Rate - physiology Kidney - drug effects Kidney - physiology Medical sciences Naloxonazine Naloxone - pharmacology Natriuresis Natriuretic peptides Opioids Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, Opioid, mu - agonists Receptors, Opioid, mu - physiology Urodilatin Vasopressin
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Zusammenfassung:	Investigation of the acute cardiovascular and renal effects of cyclo[ N ε, N β-carbonyl- d-Lys 2,Dap 5]enkephalinamide (cUENK6), the most potent μ-opioid receptor agonist, revealed dose-related effects, but most pronounced during the first hour post i.v. injections. During first hour, cUENK6 (3 μg/rat) stimulated ( P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/j.ejphar.2004.06.007