MALT lymphoma: from morphology to molecules

Hints that the growth of some lymphomas is stimulated by bacterial antigens and can be controlled by treatment with antibiotics first emerged in the 1970s. Subsequently, a specific type of B-cell lymphoma — mucosa-associated lymphoid tissue (MALT) lymphoma — was identified that is associated with ba...

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Veröffentlicht in:	Nature reviews. Cancer 2004-08, Vol.4 (8), p.644-653
Hauptverfasser:	Isaacson, Peter G., Du, Ming-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantigens Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Diagnosis Helicobacter Infections - complications Humans Immune response Lymphoma, B-Cell, Marginal Zone - genetics Lymphoma, B-Cell, Marginal Zone - immunology Lymphoma, B-Cell, Marginal Zone - pathology MALT lymphoma Physiological aspects Prevention Risk Factors timeline Translocation, Genetic
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Beschreibung
Zusammenfassung:	Hints that the growth of some lymphomas is stimulated by bacterial antigens and can be controlled by treatment with antibiotics first emerged in the 1970s. Subsequently, a specific type of B-cell lymphoma — mucosa-associated lymphoid tissue (MALT) lymphoma — was identified that is associated with bacterial infection and auto-antigen stimulation. This article chronicles the clinical, immunological and molecular developments in our knowledge of MALT lymphoma and the factors that contribute to its pathogenesis.
ISSN:	1474-175X 1474-1768
DOI:	10.1038/nrc1409