The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article

An increasing number of evidences suggest the involvement of the eukaryotic elongation factor 1A, a core component of the protein synthesis machinery, at the onset of cell transformation. In fact, eEF1A is shown to be up-regulated in cell death; moreover, it seems to be involved in the regulation of...

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Veröffentlicht in:Amino acids 2004-07, Vol.26 (4), p.443-448
Hauptverfasser: Lamberti, A, Caraglia, M, Longo, O, Marra, M, Abbruzzese, A, Arcari, P
Format: Artikel
Sprache:eng
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Zusammenfassung:An increasing number of evidences suggest the involvement of the eukaryotic elongation factor 1A, a core component of the protein synthesis machinery, at the onset of cell transformation. In fact, eEF1A is shown to be up-regulated in cell death; moreover, it seems to be involved in the regulation of ubiquitin-mediated protein degradation. In addition, eEF1A undergoes several post-translational modifications, mainly phosphorylation and methylation, that generally influence the activity of the protein. This article summarizes the present knowledges on the several extra-translational roles of eEF1A also in order to understand as the protein synthesis regulatory mechanisms could offer tools for cancer intervention.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-004-0088-2