New Genetic Abnormalities and Treatment Response in Acute Lymphoblastic Leukemia

Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the...

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Veröffentlicht in:	Seminars in hematology 2009, Vol.46 (1), p.16-23
Hauptverfasser:	Meijerink, Jules P.P, den Boer, Monique L, Pieters, Rob
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Child Child, Preschool Chromosome Aberrations Gene Expression Regulation, Leukemic Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mutation Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Transcription Factors - genetics
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Beschreibung
Zusammenfassung:	Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.
ISSN:	0037-1963 1532-8686
DOI:	10.1053/j.seminhematol.2008.09.006