New vernocuminosides from the stem barks of Vernonia cumingiana Benth

Seven new stigmastane-type steroidal glycosides, vernocuminosides A–G ( 1– 7), have been isolated from the stem barks of Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR ( 1H– 1H COSY,...

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Veröffentlicht in:Steroids 2009, Vol.74 (1), p.51-61
Hauptverfasser: Liu, Jing, Liu, Yunbao, Si, Yikang, Yu, Shishan, Qu, Jing, Xu, Song, Hu, Youcai, Ma, Shuanggang
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Sprache:eng
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Zusammenfassung:Seven new stigmastane-type steroidal glycosides, vernocuminosides A–G ( 1– 7), have been isolated from the stem barks of Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR ( 1H– 1H COSY, HSQC, HMBC, and NOE) experiments, especially the employment of Snatzke’s method expressed by the induced circular dichroism spectra. Anti-inflammatory activities and cytotoxicities of compounds 1– 7 were evaluated.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2008.09.005