New vernocuminosides from the stem barks of Vernonia cumingiana Benth
Seven new stigmastane-type steroidal glycosides, vernocuminosides A–G ( 1– 7), have been isolated from the stem barks of Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR ( 1H– 1H COSY,...
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Veröffentlicht in: | Steroids 2009, Vol.74 (1), p.51-61 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Seven new stigmastane-type steroidal glycosides, vernocuminosides A–G (
1–
7), have been isolated from the stem barks of
Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR (
1H–
1H COSY, HSQC, HMBC, and NOE) experiments, especially the employment of Snatzke’s method expressed by the induced circular dichroism spectra. Anti-inflammatory activities and cytotoxicities of compounds
1–
7 were evaluated. |
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ISSN: | 0039-128X 1878-5867 |
DOI: | 10.1016/j.steroids.2008.09.005 |