Alternative splicing of murine interleukin-4 mRNA

We found an alternative form of mRNA with spliced second exon (IL-4delta2 mRNA) in mouse bone marrow and splenic cells. At rest, the amount of IL-4 mRNA markedly surpassed that of IL-4delta2 mRNA. Stimulation increased the content of both mRNA forms, but the alternative variant is accumulated more i...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2004-02, Vol.137 (2), p.179-181
Hauptverfasser:	Yatsenko, O P, Filipenko, M L, Voronina, E N, Khrapov, E A, Sennikov, S V, Kozlov, V A
Format:	Artikel
Sprache:	eng ; rus
Schlagworte:	Alternative Splicing Animals Base Sequence Bone Marrow Cells - immunology DNA Primers - genetics DNA, Complementary - genetics Exons In Vitro Techniques Interleukin-4 - genetics Mice Mice, Inbred C57BL Mice, Inbred DBA RNA, Messenger - genetics RNA, Messenger - metabolism Spleen - cytology Spleen - immunology Tissue Distribution
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Beschreibung
Zusammenfassung:	We found an alternative form of mRNA with spliced second exon (IL-4delta2 mRNA) in mouse bone marrow and splenic cells. At rest, the amount of IL-4 mRNA markedly surpassed that of IL-4delta2 mRNA. Stimulation increased the content of both mRNA forms, but the alternative variant is accumulated more intensively and rapidly. We did not detect predominance of IL-4delta2 mRNA over full-length mRNA variant in the studied mouse tissues.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/B:BEBM.0000028134.41152.fb