Coordination ability of pentapeptides with two dehydro-amino acid residues inserted into their sequences

The study on the binding ability of tested ligands have shown that insertion of two dehydro-amino acid residues into peptide sequences makes them more effective in metal ion binding than ligands with one dehydro-amino acid residue. The ligand with two Z(Δ)Phe residue form more stable complexes than...

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Veröffentlicht in:Journal of inorganic biochemistry 2004-08, Vol.98 (8), p.1391-1398
Hauptverfasser: Brasun, Justyna, Makowski, Maciej, Ołdziej, Stanisław, Świątek-Kozłowska, Jolanta
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container_end_page 1398
container_issue 8
container_start_page 1391
container_title Journal of inorganic biochemistry
container_volume 98
creator Brasun, Justyna
Makowski, Maciej
Ołdziej, Stanisław
Świątek-Kozłowska, Jolanta
description The study on the binding ability of tested ligands have shown that insertion of two dehydro-amino acid residues into peptide sequences makes them more effective in metal ion binding than ligands with one dehydro-amino acid residue. The ligand with two Z(Δ)Phe residue form more stable complexes than his analogues with one Z(Δ)Phe residue. Interesting is this that position of Z(Δ)Phe residue in peptide chain have impact on Cu(II)-complexes formation.
doi_str_mv 10.1016/j.jinorgbio.2004.04.014
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subjects Amino Acid Sequence
Amino Acids - chemistry
Complex
Cu(II) ion
Dehydropeptide
Ions - chemistry
Ligands
Metals - chemistry
Models, Molecular
Peptides - chemistry
Peptides - genetics
Protein Binding
title Coordination ability of pentapeptides with two dehydro-amino acid residues inserted into their sequences
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