Coordination ability of pentapeptides with two dehydro-amino acid residues inserted into their sequences

The study on the binding ability of tested ligands have shown that insertion of two dehydro-amino acid residues into peptide sequences makes them more effective in metal ion binding than ligands with one dehydro-amino acid residue. The ligand with two Z(Δ)Phe residue form more stable complexes than his analogues with one Z(Δ)Phe residue. Interesting is this that position of Z(Δ)Phe residue in peptide chain have impact on Cu(II)-complexes formation.