Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5

Fibroblast growth factor 2 (FGF-2) is expressed in isoforms of different molecular masses from one mRNA species by alternative start of translation. The higher molecular mass isoforms (FGF-221 and 23) contain an arginine-rich N-terminus organized in RG-motifs followed by the 18 kDa FGF-2 (FGF-218) c...

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Veröffentlicht in:	Biological chemistry 2009-01, Vol.390 (1), p.59-65
Hauptverfasser:	Bruns, Alexander-Francisco, Grothe, Claudia, Claus, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Arginine - metabolism basic FGF Cell Line Cell Nucleus - metabolism Enzyme Inhibitors - pharmacology fibroblast growth factor Fibroblast Growth Factor 2 - chemistry Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism Humans Methylation Molecular Sequence Data Mutation nucleus PRMT protein methyltransferase Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - metabolism
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