Effect of pH on the production of the antitumor antibiotic retamycin by Streptomyces olindensis

The effect of pH on cell growth and retamycin production in batch bioreactor cultures of Streptomyces olindensis ICB20 was investigated. In fermentations pH‐controlled over the range 6.0–8.0, the highest retamycin production was achieved at pH 7.0, and the maximum concentration of retamycin, about 1...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2004-08, Vol.40 (1), p.107-111
Hauptverfasser:	Guimarães, Luciana M., De Araújo Furlan, Renata L., Garrido, Leandro M., Ventura, Armando, Padilla, Gabriel, Facciotti, Maria Cândida R.
Format:	Artikel
Sprache:	eng
Schlagworte:	anthracyclines Anthracyclines - metabolism antibiotics Antibiotics, Antineoplastic - biosynthesis antitumour Biological and medical sciences Bioreactors - microbiology Biotechnology Cell Culture Techniques - methods Cell Proliferation Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration retamycin Streptomyces Streptomyces - chemistry Streptomyces - growth & development Streptomyces - metabolism Streptomyces olindensis
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Zusammenfassung:	The effect of pH on cell growth and retamycin production in batch bioreactor cultures of Streptomyces olindensis ICB20 was investigated. In fermentations pH‐controlled over the range 6.0–8.0, the highest retamycin production was achieved at pH 7.0, and the maximum concentration of retamycin, about 1.36 A (absorbance) units, was about 43, 58 and 232% higher than the values obtained at pH 7.5, 6.0 and 8.0 respectively.
ISSN:	0885-4513 1470-8744
DOI:	10.1042/BA20030166