Is JAK2 V617F mutation more than a diagnostic index? A meta-analysis of clinical outcomes in essential thrombocythemia

Is JAK2 V617F mutation more than a diagnostic index? A meta-analysis of clinical outcomes in essential thrombocythemia

A systematic review and meta-analysis was carried out to compare the frequency of clinically significant outcomes between JAK2 V617F positive and wild type patients with essential thrombocythemia (ET). JAK2 V617F positivity in patients with ET was associated with a clear increase in the odds of thro...

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Veröffentlicht in:Leukemia research 2009-01, Vol.33 (1), p.67-73
Hauptverfasser: Dahabreh, Issa J, Zoi, Katerina, Giannouli, Stavroula, Zoi, Christine, Loukopoulos, Dimitrios, Voulgarelis, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Cell Division
Hematopoietic Stem Cells - pathology
Humans
Janus Kinase 2 - genetics
Mutation
Polycythemia Vera - genetics
Polycythemia Vera - pathology
Retrospective Studies
Thrombocythemia, Essential - genetics
Thrombocythemia, Essential - pathology
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Zusammenfassung:A systematic review and meta-analysis was carried out to compare the frequency of clinically significant outcomes between JAK2 V617F positive and wild type patients with essential thrombocythemia (ET). JAK2 V617F positivity in patients with ET was associated with a clear increase in the odds of thrombosis [OR=1.83 (95% CI, 1.32-2.53), p
ISSN:0145-2126
DOI:10.1016/j.leukres.2008.06.006