Adult invasive pneumococcal disease pre- and peri-pneumococcal conjugate vaccine introduction in a tertiary hospital in Singapore

1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2 School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore 3 Singapore General Hospital, Singapore Correspondence Li-Yang Hsu liyang_hsu{at}yahoo.com Received May 27, 2008 Accepted September 4, 2...

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Veröffentlicht in:Journal of medical microbiology 2009-01, Vol.58 (1), p.101-104
Hauptverfasser: Hsu, Li-Yang, Lui, See Weng, Lee, Jia Ling, Hedzlyn, Hazwany Md Mahrom, Kong, Debra Han-Lin, Shameen, Suku, Siti, Nur Puteri Mohammad, Tan, Wei Yu, Toh, Xin Yi, Koh, Tse-Yuen, Koh, Tse-Hsien
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Sprache:eng
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Zusammenfassung:1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2 School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore 3 Singapore General Hospital, Singapore Correspondence Li-Yang Hsu liyang_hsu{at}yahoo.com Received May 27, 2008 Accepted September 4, 2008 Streptococcus pneumoniae isolates causing invasive disease at a large tertiary institute in Singapore from 2000 to 2007 were serotyped, with 84 (43.8 %) and 159 (82.8 %) isolates belonging to serotypes covered by the pneumococcal heptavalent conjugate and polysaccharide vaccines, respectively. All non-meningitis isolates were susceptible to penicillin, and the attributable mortality was 21.4 %. Patients who fulfilled the US Advisory Committee on Immunization Practices criteria for vaccination with the pneumococcal polysaccharide vaccine comprised 74.0 % of the study cohort and had a significantly higher mortality risk. Abbreviations: ACIP, Advisory Committee on Immunization Practices; PCV7, heptavalent conjugate vaccine; PPV, 23-valent polysaccharide vaccine.
ISSN:0022-2615
1473-5644
DOI:10.1099/jmm.0.003764-0