Innate immunity in aging: impact on macrophage function

Summary Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as ‘pathogen sensors’ and play an important role in the initiation of...

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Veröffentlicht in:	Aging cell 2004-08, Vol.3 (4), p.161-167
Hauptverfasser:	Plowden, Julie, Renshaw‐Hoelscher, Mary, Engleman, Carrie, Katz, Jacqueline, Sambhara, Suryaprakash
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - immunology Aging - physiology Animals Antimicrobial Cationic Peptides - immunology Antimicrobial Cationic Peptides - physiology Cell Lineage - physiology Chemokines - secretion cytokines Cytokines - secretion Humans immunity Immunity, Innate - physiology inflammation Langerhans Cells - immunology Langerhans Cells - physiology macrophage Macrophages - immunology Macrophages - physiology Macrophages - secretion Membrane Glycoproteins - physiology Phagocytosis - immunology Phagocytosis - physiology Receptors, Cell Surface - physiology Toll-Like Receptors wound healing Wound Healing - physiology
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Beschreibung
Zusammenfassung:	Summary Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as ‘pathogen sensors’ and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.
ISSN:	1474-9718 1474-9726
DOI:	10.1111/j.1474-9728.2004.00102.x