Production of an anti-complement exo-polymer produced by Auricularia auricula-judae in submerged culture
Exo-polymer (EP) was produced at 1.2 g l(-1) in submerged culture of Auricular auricula-judae. Crude EP (AJ-0) has 70% anti-complementary activity (inhibition of total complementary hemolysis 50%; ITCH50). The activating pathway of the complement system occurred through both the classical and altern...
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| Veröffentlicht in: | Biotechnology letters 2004-06, Vol.26 (11), p.923-927 |
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| container_issue | 11 |
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| container_title | Biotechnology letters |
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| creator | JEONG, Sang-Chul CHOP, Sung-Pill YANG, Byung-Keun GU, Young-Ah JANG, Jin-Ho HUH, Tae-Lin SONG, Chi-Hyun |
| description | Exo-polymer (EP) was produced at 1.2 g l(-1) in submerged culture of Auricular auricula-judae. Crude EP (AJ-0) has 70% anti-complementary activity (inhibition of total complementary hemolysis 50%; ITCH50). The activating pathway of the complement system occurred through both the classical and alternative pathways, though the major pathway was the classical one. Fractionation of AJ-0 using Sepharose CL-6B gel chromatography gave three major fractions (AJ-Fr-I, II and III) of which the first was the most active. The mycelial growth and EP production of A. auricula-judae were optimal at pH 6, 25 degrees C and pH 5, 25 degrees C, respectively. |
| doi_str_mv | 10.1023/B:bile.0000025904.21519.3a |
| format | Article |
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Crude EP (AJ-0) has 70% anti-complementary activity (inhibition of total complementary hemolysis 50%; ITCH50). The activating pathway of the complement system occurred through both the classical and alternative pathways, though the major pathway was the classical one. Fractionation of AJ-0 using Sepharose CL-6B gel chromatography gave three major fractions (AJ-Fr-I, II and III) of which the first was the most active. The mycelial growth and EP production of A. auricula-judae were optimal at pH 6, 25 degrees C and pH 5, 25 degrees C, respectively.</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1023/B:bile.0000025904.21519.3a</identifier><identifier>PMID: 15269542</identifier><identifier>CODEN: BILED3</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Biological and medical sciences ; Biopolymers - biosynthesis ; Biopolymers - chemistry ; Biopolymers - immunology ; Biotechnology ; Cell culture ; Cell Culture Techniques - methods ; Complement Inactivator Proteins - biosynthesis ; Complement Inactivator Proteins - chemistry ; Complement Inactivator Proteins - immunology ; Fractionation ; Fundamental and applied biological sciences. 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Crude EP (AJ-0) has 70% anti-complementary activity (inhibition of total complementary hemolysis 50%; ITCH50). The activating pathway of the complement system occurred through both the classical and alternative pathways, though the major pathway was the classical one. Fractionation of AJ-0 using Sepharose CL-6B gel chromatography gave three major fractions (AJ-Fr-I, II and III) of which the first was the most active. The mycelial growth and EP production of A. auricula-judae were optimal at pH 6, 25 degrees C and pH 5, 25 degrees C, respectively.</description><subject>Biological and medical sciences</subject><subject>Biopolymers - biosynthesis</subject><subject>Biopolymers - chemistry</subject><subject>Biopolymers - immunology</subject><subject>Biotechnology</subject><subject>Cell culture</subject><subject>Cell Culture Techniques - methods</subject><subject>Complement Inactivator Proteins - biosynthesis</subject><subject>Complement Inactivator Proteins - chemistry</subject><subject>Complement Inactivator Proteins - immunology</subject><subject>Fractionation</subject><subject>Fundamental and applied biological sciences. 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Crude EP (AJ-0) has 70% anti-complementary activity (inhibition of total complementary hemolysis 50%; ITCH50). The activating pathway of the complement system occurred through both the classical and alternative pathways, though the major pathway was the classical one. Fractionation of AJ-0 using Sepharose CL-6B gel chromatography gave three major fractions (AJ-Fr-I, II and III) of which the first was the most active. The mycelial growth and EP production of A. auricula-judae were optimal at pH 6, 25 degrees C and pH 5, 25 degrees C, respectively.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>15269542</pmid><doi>10.1023/B:bile.0000025904.21519.3a</doi><tpages>5</tpages></addata></record> |
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| ispartof | Biotechnology letters, 2004-06, Vol.26 (11), p.923-927 |
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| subjects | Biological and medical sciences Biopolymers - biosynthesis Biopolymers - chemistry Biopolymers - immunology Biotechnology Cell culture Cell Culture Techniques - methods Complement Inactivator Proteins - biosynthesis Complement Inactivator Proteins - chemistry Complement Inactivator Proteins - immunology Fractionation Fundamental and applied biological sciences. Psychology Polymers Spiroplasma - growth & development Spiroplasma - metabolism |
| title | Production of an anti-complement exo-polymer produced by Auricularia auricula-judae in submerged culture |
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