Effect of Sildenafil Citrate on Retinal Functions: Preliminary Report on Humphrey Visual Field Analysis

Objective: To assess the effect of sildenafil citrate treatment on visual field analysis (VFA) in patients using sildenafil citrate for erectile dysfunction. Materials and Methods: In this prospective study on 18 male volunteers with erectile dysfunction, bilateral VFA was performed using the Humphrey 30-2 central standard threshold test. White-on-white (W/W) and blue-on-yellow (B/Y) protocols were used prior to treatment (baseline VFA) and after treatment (repeat VFA) with sildenafil citrate. W/W and B/Y baseline VFA and repeat VFA mean deviations (MD) were compared. Results: The baseline MD for W/W and B/Y protocols were –1.34 ± 1.8 and –2.59 ± 2.1 dB, respectively, whereas the mean repeat MD for W/W and B/Y protocols were –1.79 ± 2.21 and –2.83 ± 3.31 dB, respectively. There was no statistically significant difference between W/W and B/Y baseline and repeat VFA with respect to MD (p > 0.05). Conclusion: Sildenafil citrate causes no significant changes in Humphrey VFA in patients with erectile dysfunction.