Colorectal distension-induced suppression of a nociceptive somatic reflex response in the rat: modulation by tissue injury or inflammation

Inhibition of somatic nociception by conditioning noxious visceral stimulation was studied under pathophysiological conditions in rats. Viscero-somatic inhibition was enhanced following visceral inflammation and reduced by a somatic heat injury. The enhancement was reversed by an N-methyl- d-asparta...

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Veröffentlicht in:	Brain research 2004-08, Vol.1018 (1), p.106-110
Hauptverfasser:	Kalmari, Jaakko, Pertovaara, Antti
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Burns - physiopathology Colitis - physiopathology Colon - innervation Colon - physiopathology Colorectal distension Conditioning (Psychology) - physiology Diffuse noxious inhibitory controls Dizocilpine Maleate - pharmacology Down-Regulation - physiology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Hyperalgesia - physiopathology Inflammation Inflammation - chemically induced Inflammation - physiopathology Male Neural Inhibition - drug effects Neural Inhibition - physiology NMDA receptor Nociceptors - physiology Pain - physiopathology Physical Stimulation - methods Rats Rats, Wistar Reaction Time - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Rectum - innervation Rectum - physiopathology Reflex - physiology Skin - innervation Skin - physiopathology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Synaptic Transmission - drug effects Synaptic Transmission - physiology Vertebrates: nervous system and sense organs Visceral Afferents - drug effects Visceral Afferents - physiopathology Visceral pain
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Zusammenfassung:	Inhibition of somatic nociception by conditioning noxious visceral stimulation was studied under pathophysiological conditions in rats. Viscero-somatic inhibition was enhanced following visceral inflammation and reduced by a somatic heat injury. The enhancement was reversed by an N-methyl- d-aspartate (NMDA) receptor antagonist. These changes in viscero-somatic inhibition may be explained by corresponding changes in excitatory drives evoked by conditioning and test stimulation, although disinhibition may contribute to reduction of inhibition following somatic injury.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2004.05.064