Genetic variations in the matrix metalloproteinase-1 promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population

Objectives: Matrix metalloproteinase‐1 (MMP‐1) is a potent enzyme degrading extracellular matrix that was implicated in the pathogenesis of chronic periodontitis. Therefore, the aim of our study was to examine the association between three promoter polymorphisms of the MMP‐1 gene and chronic periodontitis susceptibility and/or severity in a Czech population. Materials and Methods: A total of 329 Caucasian subjects were enrolled in this study. They were 133 patients with mild to severe chronic periodontitis and 196 unrelated control subjects. MMP‐1 promoter polymorphisms (−1607 1G/2G, −519A/G, and −422A/T) were genotyped using standard polymerase chain reaction–restriction fragment length product methods. Results: Genotype analysis of the three single nucleotide polymorphisms across 27 different combinations showed significant association with chronic periodontitis (p