Rapid Synthesis of 1,3,4,4-Tetrasubstituted β-Lactams from Methyleneaziridines Using a Four-Component Reaction
2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted β-lactams in moderate to good yields (46−63%) via a “one-pot” process that brings together four components with the formation of three new intermolecular carbon−carbon bonds.
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| Veröffentlicht in: | Journal of organic chemistry 2008-12, Vol.73 (24), p.9762-9764 |
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| container_end_page | 9764 |
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| container_issue | 24 |
| container_start_page | 9762 |
| container_title | Journal of organic chemistry |
| container_volume | 73 |
| creator | Cariou, Claire C. A Clarkson, Guy J Shipman, Michael |
| description | 2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted β-lactams in moderate to good yields (46−63%) via a “one-pot” process that brings together four components with the formation of three new intermolecular carbon−carbon bonds. |
| doi_str_mv | 10.1021/jo801664g |
| format | Article |
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| ispartof | Journal of organic chemistry, 2008-12, Vol.73 (24), p.9762-9764 |
| issn | 0022-3263 1520-6904 |
| language | eng |
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| source | ACS Publications |
| subjects | Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Organic chemistry Preparations and properties |
| title | Rapid Synthesis of 1,3,4,4-Tetrasubstituted β-Lactams from Methyleneaziridines Using a Four-Component Reaction |
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