Rapid Synthesis of 1,3,4,4-Tetrasubstituted β-Lactams from Methyleneaziridines Using a Four-Component Reaction

Rapid Synthesis of 1,3,4,4-Tetrasubstituted β-Lactams from Methyleneaziridines Using a Four-Component Reaction

2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted β-lactams in moderate to good yields (46−63%) via a “one-pot” process that brings together four components with the formation of three new intermolecular carbon−carbon bonds.

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Veröffentlicht in:Journal of organic chemistry 2008-12, Vol.73 (24), p.9762-9764
Hauptverfasser: Cariou, Claire C. A, Clarkson, Guy J, Shipman, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Organic chemistry
Preparations and properties
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Beschreibung
Zusammenfassung:2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted β-lactams in moderate to good yields (46−63%) via a “one-pot” process that brings together four components with the formation of three new intermolecular carbon−carbon bonds.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo801664g