Classical and molecular cytogenetic abnormalities and outcome of childhood acute myeloid leukaemia: report from a referral centre in Israel

Summary The incidence of cytogenetic abnormalities in childhood de novo acute myeloid leukaemia (AML) and its prognostic significance was assessed in an Israeli paediatric referral centre. Cytogenetic analysis was successful in 86 of 97 children (

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Veröffentlicht in:	British journal of haematology 2004-08, Vol.126 (3), p.320-337
Hauptverfasser:	Stark, Batia, Jeison, Marta, Gabay, Leticia Glazer, Mardoukh, Jacques, Luria, Drorit, Bar‐Am, Irit, Avrahami, Gali, Kapeliushnik, Yossef, Sthoeger, Dalia, Herzel, Gavriel, Steinberg, David M., Cohen, Ian J., Goshen, Yacov, Stein, Jerry, Zaizov, Rina, Yaniv, Isaac
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Biological and medical sciences Child Child, Preschool childhood acute myeloid leukaemia Chromosome Disorders - drug therapy Chromosome Disorders - genetics Chromosome Disorders - mortality Clinical Protocols Cytogenetic Analysis cytogenetics Disease-Free Survival Female Hematologic and hematopoietic diseases Hematology Humans In Situ Hybridization, Fluorescence Infant Infant, Newborn Israel Karyotyping Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Metaphase Prognosis Retrospective Studies Survival Rate Treatment Outcome
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Beschreibung
Zusammenfassung:	Summary The incidence of cytogenetic abnormalities in childhood de novo acute myeloid leukaemia (AML) and its prognostic significance was assessed in an Israeli paediatric referral centre. Cytogenetic analysis was successful in 86 of 97 children (
ISSN:	0007-1048 1365-2141
DOI:	10.1111/j.1365-2141.2004.05038.x