Sequence-specific 1H, 13C and 15N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7

Sequence-specific 1H, 13C and 15N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7

PTPN7 is a protein tyrosine phosphatase responsible for inactivation of MAPK in leukocytes. Here we report the backbone resonance assignments of the 34 kDa phosphatase domain of human PTPN7, which is amplified in myeloid malignancies and deleted in lymphoproliferative disorders.

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Veröffentlicht in:Biomolecular NMR assignments 2008-12, Vol.2 (2), p.101-103
Hauptverfasser: Jeeves, Mark, McClelland, Darren M., Barr, Alastair J., Overduin, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Biochemistry
Biological and Medical Physics
Biophysics
Carbon Isotopes - chemistry
Catalysis
Enzymes
Leukocytes
Magnetic Resonance Spectroscopy - methods
Molecular biology
Molecular Sequence Data
Molecular Weight
Nitrogen Isotopes - chemistry
NMR
Nuclear magnetic resonance
Physics
Physics and Astronomy
Polymer Sciences
Protein Structure, Tertiary
Protein Tyrosine Phosphatases, Non-Receptor - chemistry
Proteins
Protons
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Beschreibung
Zusammenfassung:PTPN7 is a protein tyrosine phosphatase responsible for inactivation of MAPK in leukocytes. Here we report the backbone resonance assignments of the 34 kDa phosphatase domain of human PTPN7, which is amplified in myeloid malignancies and deleted in lymphoproliferative disorders.
ISSN:1874-2718
1874-270X
DOI:10.1007/s12104-008-9095-7