Oxidized LDL and paraoxanase status in ischemic stroke patients

Stroke is the leading cause of mortality and long term disability among adults in industrialized countries. Oxidative stress is an independent risk actor by inducing production of oxygen free radicals in ischemic stroke. Because a relationship may be associated between ox-ldl and paraoxanase, the aim of this study was to investigate the association between ox-ldl and paraoxanase in ischemic stroke patients by determining whether ox-ldl is a useful marker for monitoring oxidative stress in ischemic stroke patients. Our study included 100 patients of ischemic stroke and 100 controls. Compared with controls ox-ldl was significantly raised in stroke patients and Paraoxanase activity was low. Our findings suggest that there is a significant association between raised plasma ox-ldl and decrease activity of Paraoxanase with age indicating that plasma ox-ldl may reflect oxidative stress in ischemic stroke patients.