BCG Granulomatosis in Adult Mice of Different Strains with a History of Intrauterine Hypoxia

BCG Granulomatosis in Adult Mice of Different Strains with a History of Intrauterine Hypoxia

Specific features of the formation and spontaneous regression of BCG granulomas, depending on mouse genotype and history of intrauterine hypoxia, were detected in 2-month-old male CBA and C57Bl/6 mice. The numerical density of granulomas, their size and (partially) cell composition varied. There are...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.842-844
Hauptverfasser: Nadeev, A. P, Kuznetsova, I. V, Shkurupiy, V. A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
BCG granulomatosis
BCG Vaccine - adverse effects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Female
Fetal Hypoxia - physiopathology
genotype
Granuloma - etiology
Granuloma - pathology
Internal Medicine
intrauterine hypoxia
Laboratory Medicine
liver
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Morphology and Pathomorphology
Mycobacterium
Pathology
postpartum period
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Zusammenfassung:Specific features of the formation and spontaneous regression of BCG granulomas, depending on mouse genotype and history of intrauterine hypoxia, were detected in 2-month-old male CBA and C57Bl/6 mice. The numerical density of granulomas, their size and (partially) cell composition varied. There are good grounds to assume that the number of BCG granulomas in the liver, irrespective of the experimental conditions and animal strains, decreases after elimination of M. tuberculosis persisting in granuloma phagocytes and subsequent migration of cells constituting the granuloma.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0406-5