New Cholinesterase Inhibiting Bisbenzylisoquinoline Alkaloids from Cocculus pendulus

Phytochemical investigation on Cocculus pendulus (J. R. & G. FORST.) resulted in the isolation of two new and three known bisbenzylisoquinoline alkaloids. The structures of the new alkaloids, kurramine-2′-β-N-oxide (1) and kurramine-2′-α-N-oxide (2), were elucidated with the help of spectroscopi...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2004, Vol.52(7), pp.802-806
Hauptverfasser:	Atta-Ur-Rahman, Atia-Tul-Wahab, Nawaz, Sarfraz Ahmad, Choudhary, M. Iqbal
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Benzylisoquinolines - chemistry Benzylisoquinolines - isolation & purification Benzylisoquinolines - pharmacology bisbenzylisoquinoline alkaloid butyrylcholinesterase Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Cocculus Cocculus pendulus Menispermaceae Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Structures
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Zusammenfassung:	Phytochemical investigation on Cocculus pendulus (J. R. & G. FORST.) resulted in the isolation of two new and three known bisbenzylisoquinoline alkaloids. The structures of the new alkaloids, kurramine-2′-β-N-oxide (1) and kurramine-2′-α-N-oxide (2), were elucidated with the help of spectroscopic techniques. The cholinesterase inhibitory activities of these bisbenzylisoquinoline alkaloids are reported here for the first time.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.52.802