Multipotent Mesenchymal Stromal Cells of Autologous Bone Marrow Stimulate Neoangiogenesis, Restore Microcirculation, and Promote Healing of Indolent Ulcers of the Stomach

The effects of precultured multipotent mesenchymal stromal cells from autologous bone marrow on microcirculation and regeneration of experimental indolent stomach ulcer were studied in experiments on rats. It was demonstrated that precultured multipotent mesenchymal stromal bone marrow cells deliver...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-10, Vol.146 (4), p.512-516
Hauptverfasser:	Askarov, M. B., Onischenko, N. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Bone Marrow Cells - cytology Bone Marrow Cells - physiology Cell Biology Cell- and Tissue-Based Therapy Internal Medicine Laboratory Medicine Male Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - physiology Microcirculation - physiology Neovascularization, Physiologic - physiology Pathology Rats Rats, Wistar Stomach Ulcer - therapy Stromal Cells - cytology Stromal Cells - physiology Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Wound Healing - physiology
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Zusammenfassung:	The effects of precultured multipotent mesenchymal stromal cells from autologous bone marrow on microcirculation and regeneration of experimental indolent stomach ulcer were studied in experiments on rats. It was demonstrated that precultured multipotent mesenchymal stromal bone marrow cells delivered to the zone of chronic gastric ulcer stimulate neoangiogemesis, improve microcirculation in the gastric mucosa, and promote ulcer healing.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-009-0324-6