Effects of Cantharidinimides on Human Carcinoma Cells

Modification of the cantharidinimide structure led to the discovery of a novel class of antitumor compounds. These cantharidinimide derivatives containing aliphartic, aryl, and pyridyl groups showed some effect in vitro against HepG2 and HL-60 cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2004, Vol.52(7), pp.855-857
Hauptverfasser:	Lin, Lun-Huei, Huang, Hsu-Shan, Lin, Chiung-Chang, Lee, Lin-Wen, Lin, Pen-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology cantharidin Cantharidin - chemistry Cantharidin - pharmacology cantharidinimide Cell Line, Tumor Cell Survival - drug effects Cell Survival - physiology Coleoptera HepG2 HL-60 Humans Imides - chemistry Imides - pharmacology
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Beschreibung
Zusammenfassung:	Modification of the cantharidinimide structure led to the discovery of a novel class of antitumor compounds. These cantharidinimide derivatives containing aliphartic, aryl, and pyridyl groups showed some effect in vitro against HepG2 and HL-60 cells.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.52.855