Role of Cardiac Glycosides in Regulation of the Growth of Retinal Tissue Explants

We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10⁻¹³ M), strophanthin K (...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.744-746
Hauptverfasser:	Lopatina, E. V, Karetsky, A. V, Penniyaynen, V. A, Vinogradova, T. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine cardiac glycosides Cardiac Glycosides - pharmacology Cell Biology Cell Proliferation - drug effects Chick Embryo Chickens Digoxin - pharmacology Dose-Response Relationship, Drug embryo (animal) Enzyme Inhibitors - pharmacology Internal Medicine Laboratory Medicine Na⁺,K⁺-ATPase Organ Culture Techniques organotypic culture Ouabain - metabolism Ouabain - pharmacology Pathology Pharmacology and Toxicology Retina - cytology Retina - drug effects retina tissue explants Strophanthins - pharmacology
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Zusammenfassung:	We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10⁻¹³ M), strophanthin K (10⁻¹³ M) and digoxin (10⁻¹¹ M) significantly stimulated explant growth. It was hypothesized that the physiological role of endogenous oubain is associated with regulation of tissue modeling.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-009-0384-7