Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction

Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Stanley Chia, Fred Senatore, O. Christopher Raffel, Hang Lee, Frans J. Th. Wackers, Ik-Kyung Jang We aimed to determine the best cardiac biomarker to predict infarct size, left ventricular ejection fraction (LVEF), and clinical outcome in 378 patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction. We found a significant correlation between individual time-point, peak, and area-under time-concentration curve of creatine kinase (CK), CK-MB, and troponins T and I with single-photon emission computed tomography-determined infarct size and LVEF. In particular, troponin-I at 72 h (TnI72h) correlated strongly with infarct size (r > 0.70; p < 0.001) and independently predicted 180-day clinical events (hazard ratio, highest tertile = 2.3; p = 0.01). We concluded that TnI72h was a simple, effective method to estimate infarct size and LVEF after primary PCI.