Six-Month Comparison of Coronary Endothelial Dysfunction Associated With Sirolimus-Eluting Stent Versus Paclitaxel-Eluting Stent

Six-Month Comparison of Coronary Endothelial Dysfunction Associated With Sirolimus-Eluting Stent Versus Paclitaxel-Eluting Stent Jin Won Kim, Soon Yong Suh, Cheol Ung Choi, Jin Oh Na, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh This study sought to determine whether drug-eluting stent (DES) implantation is related to endothelial dysfunction at 6 months after stenting. Endothelial function was estimated by infusing acetylcholine (Ach) incrementally into the left coronary ostium (39 sirolimus-eluting stents [SES], 36 paclitaxel-eluting stents [PES] vs. 10 bare-metal stent). Abnormal vasoconstriction to Ach was observed equally in the SES and PES groups versus the bare metal stent group, especially in arterial segments distal to DES at 6 months after stenting. No differences were observed between the SES and PES groups in terms of vasoconstriction to Ach. These findings suggest that DES implantation has potential long term adverse effects on local coronary endothelial function.