Palladium-Catalyzed Reaction of 2-Hydroxy-2-methylpropiophenone with Aryl Bromides: A Unique Multiple Arylation via Successive C−C and C−H Bond Cleavages

2-Hydroxy-2-methylpropiophenone undergoes a unique multiple arylation via C−C and C−H bond cleavages upon treatment with excess aryl bromides in the presence of a palladium catalyst to give 1,1,2,2-tetraarylethanes and 4,4-diaryl-1-phenylisochroman-3-ones.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2004-07, Vol.126 (28), p.8658-8659
Hauptverfasser:	Wakui, Hiroyuki, Kawasaki, Satoshi, Satoh, Tetsuya, Miura, Masahiro, Nomura, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Carbon - chemistry Catalysis Chemistry Exact sciences and technology Hydrocarbons, Brominated - chemistry Hydrogen Bonding Kinetics and mechanisms Molecular Structure Organic chemistry Palladium - chemistry Propiophenones - chemical synthesis Propiophenones - chemistry Reactivity and mechanisms
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Beschreibung
Zusammenfassung:	2-Hydroxy-2-methylpropiophenone undergoes a unique multiple arylation via C−C and C−H bond cleavages upon treatment with excess aryl bromides in the presence of a palladium catalyst to give 1,1,2,2-tetraarylethanes and 4,4-diaryl-1-phenylisochroman-3-ones.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja0477874