Identification of a new HLA-DRB1 allele in three members of an Italian family

Identification of a new HLA-DRB1 allele in three members of an Italian family

A new human leucocyte antigen (HLA)‐DRB1 allele, HLA‐DRB1*1149, has been identified in three members of an Italian family during routine sequence based typing. This new allele differs from HLA‐DRB1*110101 only for a single nucleotide substitution at position 113 of exon 2 resulting in an amino acid...

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Veröffentlicht in:Tissue antigens 2004-08, Vol.64 (2), p.210-212
Hauptverfasser: Garino, E., Berrino, M., Mazzola, G., Boccadoro, M., Bruno, B., Bertinetto, F., Bertola, L., Caropreso, P., Frisaldi, E., Marin, F., Panniello, M. L., Tondat, F., Dall'Omo, A. M.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
bone marrow transplantation
HLA-DR Antigens - genetics
HLA-DRB1
HLA-DRB1 Chains
Humans
Italy
Molecular Sequence Data
new allele
Sequence Alignment
sequence based typing
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Zusammenfassung:A new human leucocyte antigen (HLA)‐DRB1 allele, HLA‐DRB1*1149, has been identified in three members of an Italian family during routine sequence based typing. This new allele differs from HLA‐DRB1*110101 only for a single nucleotide substitution at position 113 of exon 2 resulting in an amino acid change from Valine (GTG) to Alanine (GCG) at codon 38.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.2004.00262.x